About AlloPipe
AlloPipe is a computational tool designed for large-scale genomic comparisons between two human samples which has been developed in the context of transplantation - whether of Solid Organ Transplantation (SOT) or Haematopoietic Cell Transplantation (HCT).
From high throughput sequencing data - such as Whole Exome Sequencing (WES) or Whole Genome Sequencing (WGS) - AlloPipe returns the genomic differences between the donor and the recipient that meet the users specifications in terms of:
- Protein impact (synonymous/non-synonymous polymorphisms, early stop codon)
- Protein expression (restriction to a transcript list)
- Genomic localisation (restriction to a bedfile)
This tool therefore provides insights onto non-HLA polymorphisms potentially triggering indirect alloreactivity.
Our mission is to enhance transplantation outcomes by developing innovative tools for better donor/recipient matching and personalized immunosuppressive therapies.
AlloPipe Features
- Compares exomes within two samples and returns the implied amino acid differences.
- Can be applied to both solid organ transplantation and haematopoietic stem cell transplantation.
- Available on GitHub with an easy installation process and few requirements.
Our Team
Hugues Richard
Sorbonne Université & Robert Koch Institut
Adèle Dhuyser
CHRU de Nancy & Université de Lorraine
Alice Aarnink
CHRU de Nancy & Université de Lorraine
Laurent Mesnard
Sorbonne Université & AP-HP
Pierre Laville
Sorbonne Université & Eurofins-Biomnis