About AlloPipe

AlloPipe is a computational tool designed for large-scale genomic comparisons between two human samples which has been developed in the context of transplantation - whether of Solid Organ Transplantation (SOT) or Haematopoietic Cell Transplantation (HCT).

From high throughput sequencing data - such as Whole Exome Sequencing (WES) or Whole Genome Sequencing (WGS) - AlloPipe returns the genomic differences between the donor and the recipient that meet the users specifications in terms of:

  • Protein impact (synonymous/non-synonymous polymorphisms, early stop codon)
  • Protein expression (restriction to a transcript list)
  • Genomic localisation (restriction to a bedfile)

This tool therefore provides insights onto non-HLA polymorphisms potentially triggering indirect alloreactivity.

Our mission is to enhance transplantation outcomes by developing innovative tools for better donor/recipient matching and personalized immunosuppressive therapies.

AlloPipe Features

  • Compares exomes within two samples and returns the implied amino acid differences.
    Allo-Count
  • Can be applied to both solid organ transplantation and haematopoietic stem cell transplantation.
    Flexibility
  • Available on GitHub with an easy installation process and few requirements.
    Open Source

Our Team

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Hugues Richard

Sorbonne Université & Robert Koch Institut

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Adèle Dhuyser

CHRU de Nancy & Université de Lorraine

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Alice Aarnink

CHRU de Nancy & Université de Lorraine

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Laurent Mesnard

Sorbonne Université & AP-HP

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Pierre Laville

Sorbonne Université & Eurofins-Biomnis