About AlloPipe

AlloPipe is a computational tool designed for large-scale genomic comparisons between two human samples which has been developed in the context of transplantation - whether of Solid Organ Transplantation (SOT) or Haematopoietic Cell Transplantation (HCT).

From high throughput sequencing data - such as Whole Exome Sequencing (WES) or Whole Genome Sequencing (WGS) - AlloPipe returns the genomic differences between the donor and the recipient that meet the users specifications in terms of:

• Protein impact (synonymous/non-synonymous polymorphisms, early stop codon)
• Protein expression (restriction to a transcript list)
• Genomic localisation (restriction to a bedfile)

This tool therefore provides insights onto non-HLA polymorphisms potentially triggering indirect alloreactivity.

Our mission is to enhance transplantation outcomes by developing innovative tools for better donor/recipient matching and personalized immunosuppressive therapies.